Friday, May 12, 2017

A Life Saving Diet - The Ketogenic Diet REVERSES Diabetic Kidney Disease

Researchers have shown that a ketogenic diet reverses diabetic kidney disease in animals. 
"Diabetic nephropathy, as indicated by albumin/creatinine ratios as well as expression of stress-induced genes, was completely reversed by 2 months maintenance on a ketogenic diet....Whether reduced glucose metabolism mediates the protective effects of the ketogenic diet remains to be determined." (1)
Further, the researchers determined that the reversal of cellular dysfunction was brought about by ketones protecting the cells from glucose-induced oxidative stress.
"To further assess potential mechanisms mediating the protective effects of the ketogenic diet, and since glucose toxicity in diabetes is thought to be mediated by glucose-induced oxidative stress, we assessed if the ketone 3-OHB would protect cells from oxidative stress enhanced by either high or low glucose. As shown in Figure 6, ,3-OHB3-OHB produced a dose-responsive cytoprotective effect at both elevated and reduced glucose." (1)
No other dietary approach has ever done this.  The conventional diet for kidney disease is low protein, but protein restriction has never been reported to reverse the disorder. 

However, in the video interview of the researchers (below), they say that they don't want diabetics to adopt a ketogenic diet.  They claim to be worried that eating a high fat diet could cause other problems.  Instead, they want to create a drug to replicate the effects of the diet.

What "other problems" are they afraid of?  Are they really worried about your health?  Or are they warning you away from the diet in order to preserve their customer base for the drug they want to create?  What if a ketogenic diet reversed diabetes?
"By 10 weeks, 133/234 (56.8%) individuals had one or more diabetes medications reduced or eliminated. At follow-up, 47.7% of participants (125/262) achieved an HbA1c level of less than 6.5% while taking metformin only (n=86) or no diabetes medications (n=39). Mean body mass reduction was 7.2% (SD 3.7%; 95% CI 5.8% to 7.7%, P less than .001) from baseline (117, SD 26, kg).
"These initial results indicate that an individualized program delivered and supported remotely that incorporates nutritional ketosis can be highly effective in improving glycemic control and weight loss in adults with T2D while significantly decreasing medication use."(2)
Reducing or eliminating medications?  Now that's a problem for a drug company or someone who wants to cash in by developing a drug to sell to a drug company.  We can't have people curing their diabetes or kidney disease with a ketogenic diet, that would cut into pharmaceutical profits.

So you better be really, really scared of eating fat.   

Can you say "conflict of interest?" 

When you fast, your body eats your own animal fat.  That human body fat is about 43% saturated and 47% monounsaturated fatty acids.  It is very similar to the fat in all other mammals.  If you eat a high carbohydrate diet, your liver will convert the vast majority of your dietary carbohydrate into saturated and monounsaturated fats in that proportion. (It can't produce polyunsaturated fats.)

It has no other choice.  A high carbohydrate meal contains too much sugar to safely allow into the blood stream.  So insulin is released to cause the body to convert the glucose into fatty acids, and those are stored in your adipose, from which they are released between meals. 

Why was Nature so stupid to store such a toxic substance (saturated fat) for fuel IN ALL MAMMALS?

Burning dietary animal fats is no more dangerous than burning your own body fat during a fast (which a lot of people would love to do).

Our ancestors were fat hunters and could not have survived the Pleistocene without eating a fat-based diet.

Yet these scientists are programmed to think high fat diets are dangerous, or at least they want to program you to think so!

Would you rather eat a ketogenic diet and reverse your diabetes or kidney disease, or be on dialysis?


1.  Poplawski, Michal M. et al. “Reversal of Diabetic Nephropathy by a Ketogenic Diet.” Ed. Krisztian Stadler. PLoS ONE 6.4 (2011): e18604. PMC. Web. 10 May 2017. 

2. McKenzie AL, Hallberg SJ, Creighton BC, Volk BM, Link TM, Abner MK, Glon RM, McCarter JP, Volek JS, Phinney SD.  A Novel Intervention Including Individualized Nutritional Recommendations Reduces Hemoglobin A1c Level, Medication Use, and Weight in Type 2 Diabetes
JMIR Diabetes 2017;2(1):e5


Yuri said...

Hi Don,

I like each post of your blog.
You wrote in the post : "High Animal Protein Intake Reduces Frailty and Increases Survival In Japanese & Okinawan Elders":

"The table also shows intake of at least 1.8 g/d of methionine was also associated with the lowest risks for frailty. Animal proteins are the best sources of methionine. This might call into question the idea that methionine restriction is a viable method for promotion of life span. Such restriction may lead to frailty, which leads to premature disability and often death from falling."

You support a Ketogenic diet but the article: "Methionine and choline regulate the metabolic phenotype of a ketogenic diet" (PMCID: PMC3773836: have a conflict between the benefits of ketogenic diet with methionine:

"Ketogenic diet in mice induces a unique metabolic profile characterized by weight loss, low glucose, high ketones and increased energy expenditure [10]. Although it is assumed that the metabolic profile of KD depends on the absence of carbohydrates and on the high fat content, recent work suggested that weight gain and induction of ketosis depends on the relative fat to protein ratio in the ketogenic diet "

"We have found that choline was more effective than methionine in decreasing the liver steatosis of KD-fed mice. On the other hand, methionine supplementation was more effective than choline in restoring weight gain and normalizing the expression of several fatty acid and inflammatory genes in the liver of KD-fed mice. Our results indicate that choline and methionine restriction rather than carbohydrate restriction underlies many of the metabolic effects of KD."

High protein and high fat is problematic too?.
The concept "ancestral diet" is a toxic axiom?.


Don Matesz said...


In that paper they are investigating the effects of a specific KD, formulated for rodents, which contains only 10% protein. This diet produces fatty liver in mice, because it is deficient in methionine and choline, both of which are lipotropic factors.

So these researchers were trying to figure out why mice eating the formula KD get fatty liver, loss of lean mass, inflammation, and bone loss.

This has little or no relevance to humans consuming KD since typically humans eating KD eat 15-20% protein and consume plenty of choline from egg yolks. As I have already blogged, far from losing lean mass on KD, humans gain more muscle on a KD than on a conventional diet. So, suggesting that loss of lean mass is a characteristic of KD application in humans is just wrong.

The point is, rodents are not a completely satisfactory model for study of KD. We have no reason to believe that rodents were naturally selected by evolution for low carbohydrate diets. In contrast, we have lots of evidence that humans were so selected over at least 2 million years of evolution. Thus, the fact that rodents experience some adverse effects on KD does not predict same in humans. Note that the authors of this study did not provide any reference documenting these same adverse effects in humans.

In the last paragraph of that paper you will find: "Limiting methionine content of KD contributes to weight loss, increased expression of fatty acid oxidation and inflammatory genes while the low choline contributes to fatty liver. Thus supplementation of each specific nutrient corrects distinct metabolic consequences of KD."

In summary, all these authors did was show why rodents get fatty liver and lean mass loss on a KD, namely, the KD diet given to them is low in methionine and choline. Since humans eating KD don't typically have restricted methionine or choline intakes, yet they lose fat and gain muscle, this report doesn't tell us anything about the KD for humans.