Friday, October 3, 2014

Cracking the Large Fluffy Myth

Dr. Greger discusses research casting doubt on the idea promoted by the egg industry that large fluffy LDL protects against atherosclerosis or coronary heart disease.  The studies he cites indicate that having large LDL particles predominating does not substantially reduce risk relative to having small LDL particles, but still increases risk relative to having low total LDL.[ 1, 2 ]

Mora et al studied women and reported "However, when small and large LDLNMR were examined in a model that included all 9 NMR-measured lipoprotein particle concentrations (data not shown), both large and small LDLNMR were significantly associated with CVD to a similar degree." [ 1] They also found that small dense HDL appeared to increase risk of CVD.

Otvos et al studied men and reported "Both large and small LDL subclass particle numbers were now strongly and independently predictive of CHD outcomes, both at baseline and during the trial. ORs for small and large LDL-P during the trial were 1.41 (95% CI, 1.14 to 1.73; P=0.001) and 1.34 (95% CI, 1.11 to 1.62; P=0.002), respectively." [2 ] In their population, small LDL increased risk by 41%, and large LDL by 34%; similar risk regardless of particle size (at any give total LDL concentration).  They found "Mean LDL and HDL particle sizes were not associated with CHD events."


Charles Grashow said...

Lipoprotein Particle Profiles by Nuclear Magnetic Resonance Compared with Standard Lipids and Apolipoproteins in Predicting Incident Cardiovascular Disease in Women

"In this prospective cohort of 27,673 initially healthy women, we found that NMR-measured lipoproteins were significantly associated with incident CVD after adjusting for non-lipid risk factors, with a magnitude of risk comparable but not superior to standard lipids or immunoassay-measured apolipoproteins. Even though NMR-measured LDLNMR particle concentration performed well for CVD risk prediction in this study, and was similar in risk to apolipoprotein B100, neither measurement was better than the total/HDL cholesterol ratio which is readily obtained from a standard lipid panel. These data support current guidelines that recommend the use of a standard lipid panel, in particular the total/HDL cholesterol ratio, for CVD risk assessment in clinical practice."

In sum, CVD risk prediction associated with NMR lipoprotein profiles in this large prospective cohort of women was comparable but not superior to standard lipids or immunoassay-measured apolipoproteins. Thus, our data support the use of standard lipids, in particular the total/HDL cholesterol ratio, which are highly effective and readily available, for routine CVD risk assessment."

Anonymous said...

ALL science can ever do is say if something is more likely or less likely. Science does NOT prove anything. Science only shows us what is wrong. Let me make all of this CLEAR!

This vegan doctor in he video is distorting everything to fit his dogma.....

Vegans: Just because your idea satisfies the test of experiment does NOT mean your idea satisfies the test of ALL experiments. There are many more things in the universe that we DO NOT understand than what we understand.

Most scientific ideas are wrong. Lots and lots of JUNK is published in the peer-reviewed literature. Simply being published means NOTHING. Most experiments are wrong, the first time they are done. All of this comes from top science educators such as Dr. Krauss and Dr. Filippenko. You people are misinformed. All of you ....