Wednesday, September 18, 2013

Starving Cancer With Methionine Restriction



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fatty foods destroys the stomach’s signals to the brain - See more at: http://www.biospectrumasia.com/biospectrum/news/195812/why-dieters-regain-weight-losing#.Ujnczxlbv4g Read more at: http://www.biospectrumasia.com/biospectrum/news/195812/why-dieters-regain-weight-losing#.Ujnczxlbv4g
A latest research conducted by the New University of Adelaide has established the reason why dieters tend to regain the weight after losing it. It showed that indulging in a high-fat diet can destroy the stomach's signals to the brain. The research found that the nerves in the stomach that signal fullness to the brain appeared to be de-sensitized after long-term consumption of a high-fat diet. The study led by Associate Professor Amanda Page had a PhD student Stephen Kentish investigating the impact of high-fat diets on the ability of the gut to signal its fullness, and also to find whether those changes revert back to normal by losing weight. Associate Professor Page explained in the report that laboratory studies showed that the stomach's nerve response does not return to normal upon a return to a normal diet. "This means you would need to eat more food before you felt the same degree of fullness as a healthy individual. A hormone in the body, Leptin, known to regulate food intake, can also change the sensitivity of the nerves in the stomach that signal fullness. In normal conditions, leptin acts to stop food intake. However, in the stomach in high-fat diet induced obesity, leptin further de-sensitizes the nerves that detect fullness, she said. - See more at: http://www.biospectrumasia.com/biospectrum/news/195812/why-dieters-regain-weight-losing#.Ujnczxlbv4g Read more at: http://www.biospectrumasia.com/biospectrum/news/195812/why-dieters-regain-weight-losing#.Ujnczxlbv4g
A latest research conducted by the New University of Adelaide has established the reason why dieters tend to regain the weight after losing it. It showed that indulging in a high-fat diet can destroy the stomach's signals to the brain. The research found that the nerves in the stomach that signal fullness to the brain appeared to be de-sensitized after long-term consumption of a high-fat diet. The study led by Associate Professor Amanda Page had a PhD student Stephen Kentish investigating the impact of high-fat diets on the ability of the gut to signal its fullness, and also to find whether those changes revert back to normal by losing weight. Associate Professor Page explained in the report that laboratory studies showed that the stomach's nerve response does not return to normal upon a return to a normal diet. "This means you would need to eat more food before you felt the same degree of fullness as a healthy individual. A hormone in the body, Leptin, known to regulate food intake, can also change the sensitivity of the nerves in the stomach that signal fullness. In normal conditions, leptin acts to stop food intake. However, in the stomach in high-fat diet induced obesity, leptin further de-sensitizes the nerves that detect fullness, she said. - See more at: http://www.biospectrumasia.com/biospectrum/news/195812/why-dieters-regain-weight-losing#.Ujnczxlbv4g Read more at: http://www.biospectrumasia.com/biospectrum/news/195812/why-dieters-regain-weight-losing#.Ujnczxlbv4g

8 comments:

Healthy Longevity said...

Here are a couple papers on methionine restriction as a life extension strategy:
http://www.oasisofhope.com/media/pdf/met_vegan.pdf
http://www.nutritionj.com/content/10/1/107

This paper shows that casein is still far more cancer promoting in animals compared to soy protein even when the casein and soy protein diets were formulated to contain equivalent amounts of the limiting amino acid methionine.
http://jn.nutrition.org/content/125/3_Suppl/698S.full.pdf

Swede said...

I guess I'll stop taking my daily caesin meal, since it is giving me breast cancer.

This is the same crap the China Study guy used. Isolate one small component of an animal food, give it to rats in supra-physiological doses, and when the cancer develops, blame it on the original food source of said component. Great science, guys.

The "study" (really just a review article) contains such great quotes as: "the 20% soy diet produced less tumors than the caesin diet..." Well, how much caesin were they given and how so? Read this again, it is weak Don.

Ralph Nader once said that Democrats and Republicans were now the same. Vegans and Paleos also seem to be cut from the same cloth.

Don said...

Swede,

Do tumor cells require more methionine than normal cells?

Do animal foods have a greater or lesser methionine concentrations (g/kcal) than plant foods?

How does the methionine content of isolated casein differ from that of whole milk protein (g Met/g total PRO)? How does it differ from whole meat protein?

How does the Met content of human milk compare to that of meat or milk (g/kcal)?

How does the Met content of whole peas, soybeans or lentils compare to that of whole milk, salmon, chicken, beef, or eggs, on a g Met/g total protein basis?

How does the Met content of a plant-based diet compare to that of a meat-rich diet?

How does comparing the effects of a diet consisting of 20% isolated soy protein to one consisting of 20% isolated casein violate scientific standards?

How does isolating the protein change the effects of the constituent amino acids on tumor growth?

Does the idea that high methionine content animal foods promote cancer conflict with or is it consistent with other lines of evidence (e.g. case-control, epidemiological, experimental)?

Why do you call 20% protein (whether casein or soy) supraphysiological?


Here is a standard rat chow from Purina:
http://www.labdiet.com/cs/groups/lolweb/@labdiet/documents/web_content/mdrf/mdi4/~edisp/ducm04_028021.pdf

It is described as "the rodent diet standard for biomedical research" for 70 years, formulated with 'high quality animal protein' for 'optimum performance.' It has a crude protein content of 23% and 29% of calories are from protein.

If this is the standard for rodent diets, how can 20% casein (or soy protein) be considered 'supraphysiological'?

How do you explain the fact that, as detailed in this review, so many different researchers/laboratories produced similar results in dozens of experiments?

Swede said...

Let's say you have a 2500 kcal daily diet.

20% protein would be 500 kcals.

If your diet was 20% caesin, which is about 80% of the protein in milk, you would be consuming:

500 kcals protien / 4 kcals per gram = 125 grams protein.

125 grams protein, if consumed as caesin (which is about 80% of milk protein), would be 125/0.8 = ~156 g milk protein.

156 g milk protein / 8 grams protein per cup of milk =.....

19.5 cups of milk!!!!!

Swede said...

But if consumed as whole milk, that would amount to ~3000 kcals, which would then make the diet only ~16.6% caesin.

Swede said...

I just died from methionine excess (or restriction, I can't tell).

Don said...

Schloss JV. On the Origin of Western Diet Pathologies. Nature Precedings 07/2010; DOI:http://hdl.handle.net/10101/npre.2010.4641.1.

Charles Grashow said...

Don

Will you be taking another NMR/VAP test soon? We are curious if your diet is reducing your TC and LDL to your target levels (TC 150, LD 70 or less)

If not will you consider using statins ala Dr. Esselstyn?