Wednesday, December 29, 2010

A Practically Primal Perspective on Conventional Beef, Part 1: Hormones

Some people wonder if one can safely eat conventional meat as a part of a practically paleo lifestyle.   Documentary films like Food Inc, along with a plethora of anti-meat, pro-vegetarian literature, have given people the impression that conventional meat products come from inhumane production systems and that conventional meat contains hazardous amounts of hormones, antibiotics, and pesticide residues.  Shall we believe this?  Let’s take a look, starting with hormones.


Does conventional meat contain hazardous levels of hormones?  Short answer:  No.  For details, read on.

First, a primal perspective.

I once had a native African explain to me that among her people, they have a taboo against hunting female animals.   This taboo makes a lot of sense for a tribe dependent on hunting.  If you kill a female, you are eliminating a bunch of potential offspring at the same time; while killing a few bulls will have essentially no effect on the fecundity of the herd. 

So hunters would have preferred eating bulls to cows, and in Europe still today some producers  raise bulls.  Similarly, in the U.S. we get most of our beef from steer—neutered bulls—while we save the cows for calving and milk production.  

Bulls and steer differ hormonally.  Bull meat samples tested by Fritsche and Steinhart [1] contained medians of 0.34 mg/kg testosterone and 0.32 mg/kg epitestosterone, while steer meat samples (from unsupplemented steers) contain medians of 0.01 mg/kg testosterone and 0.12 mg/kg epitestosterone.   Bull meat had up to 1.05 mg/kg testosterone.  Thus, bull meat contains a median of 34 times more testosterone and more than twice as much epitestosterone than steer meat; and bull meat might have up to 105 times as much testosterone as a steer.

Their data indicates that at least some of the meat typically eaten by hunter-gatherers would have had  between eight and one hundred times more endogenous steroid hormone—in the form of testosterone— than an untreated modern “organic” steer.  Thus, it would seem that through evolution humans adapted to consumption of meat containing considerably greater levels of steroid hormone than what we find in a modern untreated or “organic” steer meat.

Since testosterone promotes muscle tissue growth, a steer has much less growth potential than a bull.  However, testosterone also makes bulls aggressive and harder to handle, so we can more easily control steers.  Modern husbandry attempts to restore the growth potential without the aggression by substituting for a small amount of the lost testosterone other anabolic but less androgenic steroids, primarily estrogens.

Currently the FDA allows the use of five hormones in cattle for meat production: progesterone, testosterone, estradiol-17β, zeranol, and trenbolone acetate.

The first three are natural hormones, the same as produced by an intact animal.   Zeranol occurs naturally also,  produced by fungi.   It acts as a non-steroidal estrogen agonist, meaning it acts like estrogen. Trenbolone acts as an androgenic steroid that promotes muscle growth.

Does the use of these in raising cattle result in meat or dairy products with unusually high, potentially harmful levels of dietary estrogens or other steroids? 

According to Doyle [2], four studies have found that muscle meat from an untreated steer provides estrodiol in a range of 2.8-14.4 pg/g.  Two other studies found estrodiol at concentrations of 12 pg/g in liver, and 12.6 pg/g in kidney.   Doyle also cites an FAO report finding that meat from implanted steers had 9.7 pg/g estrodiol at 15 days after implantation, and 7.3 pg/g at 61 days after implantation.  In short, the levels of estrodiol in hormone-treated meat falls in the normal range found in meat from untreated cattle.  Doyle comments:

“Estradiol levels in edible tissues of implanted cattle are usually significantly higher than in controls but the increases are small, in the ng/kg range. The greatest increases reported in an FAO report on estradiol residues were 0.002, 0.0065, 0.005, and 0.0084 mg/kg for implanted bulls, steers, heifers, and calves, respectively. These increases are well below the FDA recommended limits listed in the table on p. 2 and well below estradiol concentrations in muscles of pregnant heifers (0.016 to 0.033 mg/kg).”

Similarly, Hartmann, Lacorn, and Stienhart examined the “Natural occurrence of steroid hormones in food.” [3]  Using gas chromatography-mass spectrometry, they measured the levels of twelve steroids occurring in market-sourced meats, milk products, plants, yeast, and alcoholic beverages, including both naturally occurring and residues of additional hormones used in production.  They tested beef (bull, steer, heifer), veal, pork, poultry, eggs, fish, and plants (potatoes, wheat, rice, soybeans, haricots beans, muschrooms, olive oil, safflower oil, and corn oil). 

They found no significant difference in hormone levels between meat from hormone-treated and untreated animals.  In the typical diet, meat, poultry, and eggs proved to supply less hormones than non-paleo milk products :

“Meat does not play a dominant role in the daily intake of steroid hormones. Meat, meat products and fish contribute to the hormone supply according to their proportion in human nutrition (average about one quarter). The main source of estrogens and progesterone are milk products (60-80%). Eggs and vegetable food contribute in the same order of magnitude to the hormone supply as meat does.”

Thus, if you eat a paleo diet, and avoid milk products, you actually would eliminate the greatest dietary source of estrogens, and might reduce your total dietary intake of estrogens by more than 50%.

As for health effects of these hormones in foods, Hartmann et al compared the intake of hormones from diet from all sources to natural human hormone production levels, concluding that the food contents of steroids are insignificant compared to endogenous production [p. 18]:

“These values [amounts provided by diet] are far exceeded by the human steroid production (Table 10). Children, who show the lowest production of steroid hormones, produce about 20 times the amount of progesterone and about 1000 times the amount of testosterone and estrogens that are ingested with food on average per day. It has further to be taken into consideration that about 90% of the ingested hormones are inactivated by the first-pass-effect of the liver.  This leads to the conclusion that no hormonal effects, and as a consequence no tumor promoting effects, can be expected from naturally occurring steroids in food.”

For example, a prepubertal boy, most vulnerable to adverse effects of excess dietary estrogens,  produces about 100 micrograms of estrogen daily.  Beef muscle meat contains less than 0.02 micrograms of estrogens per kilogram.  To get from beef an intake of estrogens equal to just one percent of his endogenous estrogen production, i.e. 1 microgram, he would have to consume 50 kilograms--110 pounds-- of beef in a day!  

According to Doyle [2], the lowest observed effect level of exogenous estrogen is 5 micrograms of estrogens per kilogram of body weight.  Thus, a 40 kg prepubertal boy would have to consume 200 micrograms of estrogens daily to observe an effect.  To get this from conventional hormone-treated beef, he would have to consume 10,000 kg of beef every day.  Clearly he isn't going to get feminized by eating beef.

Opponents of the use of hormones in modern animal husbandry often claim that the use of hormones in production of meat and dairy products causes early puberty, obesity, and cancer in modern industrial nations.

Cornell University has a website discussing these Consumer Concerns About Hormones in Foods:

Can steroid hormones in meat affect the age of puberty for girls?
Early puberty in girls has been found to be associated with a higher risk for breast cancer. Height, weight, diet, exercise, and family history have all been found to influence age of puberty (see BCERF Fact Sheet #08, Childhood Life Events and the Risk of Breast Cancer). Steroid hormones in food were suspected to cause early puberty in girls in some reports. However, exposure to higher than natural levels of steroid hormones through hormone-treated meat or poultry has never been documented. Large epidemiological studies have not been done to see whether or not early puberty in developing girls is associated with having eaten growth hormone-treated foods.
A concern about an increase in cases of girls reaching puberty or menarche early (at age eight or younger) in Puerto Rico, led to an investigation in the early 1980s by the Centers for Disease Control (CDC). Samples of meat and chicken from Puerto Rico were tested for steroid hormone residues. One laboratory found a chicken sample from a local market to have higher than normal level of estrogen. Also, residues of zeranol were reported in the blood of some of the girls who had reached puberty early. However, these results could not be verified by other laboratories. Following CDC's investigation, USDA tested 150 to 200 beef, poultry and milk samples from Puerto Rico in 1985, and found no residues of DES, zeranol or estrogen in these samples.
In another study in Italy, steroid hormone residues in beef and poultry in school meals were suspected as the cause of breast enlargement in very young girls and boys. However, the suspect beef and poultry samples were not available to test for the presence of hormones. Without proof that exposure to higher levels of steroid hormones occurred through food, it is not possible to conclude whether or not eating hormone-treated meat or poultry caused the breast enlargement in these cases.
Can eating meat from hormone-treated animals affect breast cancer risk?
Evidence does not exist to answer this question. The amount of steroid hormone that is eaten through meat of a treated animal is negligible compared to what the human body produces each day. The breast cancer risk of women who eat meat from hormone-treated animals has not been compared with the risk of women who eat meat from untreated animals.

Similarly, we don't have any studies of comparing the prostate cancer risk of men who eat meat from hormone-treated animals to men who eat meat from untreated animals.

In Hyperinsulinemic Diseases of Civilization:  More Than Just Syndrome X, Cordain, Eades, and Eades [4] point out that current evidence actually implicates high carbohydrate intake as the promoter of these hormone-related disorders, because high carbohydrate intake raises insulin levels which increases levels of insulin-like growth factors and increases endogenous production of steroids, by far the main source of steroid exposure, while reducing sex hormone-binding globulins that reduce steroid activity. In the abstract they summarize:

Specifically, hyperinsulinemia elevates serum concentrations of free insulin-like growth factor-1 (IGF-1) and androgens, while simultaneously reducing insulin-like growth factor-binding protein 3 (IGFBP-3) and sex hormone-binding globulin (SHBG). Since IGFBP-3 is a ligand for the nuclear retinoid X receptor a, insulin-mediated reductions in IGFBP-3 may also influence transcription of anti-proliferative genes normally activated by the body’s endogenous retinoids. These endocrine shifts alter cellular proliferation and growth in a variety of tissues, the clinical course of which may promote acne, early menarche, certain epithelial cell carcinomas, increased stature, myopia, cutaneous papillomas (skin tags), acanthosis nigricans, polycystic ovary syndrome (PCOS) and male vertex balding. Consequently, these illnesses and conditions may, in part, have hyperinsulinemia at their root cause and therefore should be classified among the diseases of Syndrome X. [Italics added]

Using the paleo principle to evaluate this claim, we should expect ill effects of hormones in meat to appear in heavy meat-eating hunter-gatherer groups since they ate meat from intact animals, particularly bulls having 10 times as much testosterone as domesticated animals.

Alas for the hormone hypothesis, hunter-gatherers eating strictly native foods had no obesity, and, so far as we can tell, no cancer. [5]  Further, in The Paleolithic Prescription, S. Boyd Eaton, M.D., Melvin Konner M.D., Ph.D., and Marjorie Shostak present data on reproductive milestones among recent hunter-gatherers.  Among three recent hunter-gatherer tribes (Agta, !Kung, Ache), the average age of menarche (onset of menses) is about 16 years of age, compared to 12.5 years in the U.S. according to Wikipedia.

Since hunter-gatherers eating bull meat on a regular basis and consuming around 50% of energy from meat had none of the problems attributed to hormones in meat, it seems unlikely that hormones in meat can account for cancer or any other hormone-related problem in modern people.

I prefer to see people eat meat from animals not treated with hormones or hormone analogues, but if for budget reasons you choose to eat conventional meat (hormone treated or not) instead of grass fed, I think you don't need to worry that its hormone content will harm you in any way.  You should worry more that by avoiding the meat, you will consume too many carbohydrates that will much more profoundly alter your endocrine system in harmful directions.

But before you get meat from hormone-treated animals, check to see if you can find a supplier for meats from animals raised on typical feeds (corn, soy, etc.) but without added hormones.  In Phoenix, we have at least two markets--Sprouts and Sunflower--that supply meat that comes from such animals. These markets sell their meats at prices comparable and sometimes lower than what I see at more conventional supermarkets where the meat comes from hormone-treated animals.

We will look at antibiotics and other issues in upcoming posts.

Thanks to Matt Schoeneberger, co-author of S.P.E.E.D. Weight Loss Book, for help accessing one of the articles I used as a reference for this article.  


1. Fritsche S and Steinhart H. Differences in natural steroid hormone patterns of beef from bulls and steers.  J. Anim. Sci. 1998. 76:1621–1625.  Full text:

2.  Doyle E.  Human Safety of Hormone Implants Used to Promote Growth in Cattle:
A Review of the Scientific Literature.  Food Research Institute, University of Wisconsin
Madison, WI 53706.  Full text:

3.  Hartmann S, Lacorn M, and Stienhart H. Natural occurrence of steroid hormones in food. Food Chemistry 62(1);7-20 

4.  Cordain L, Eades M, Eades M.  Hyerinsulinemic diseases of civilization: More than just syndrome X.  Comparative Biochemistry and Physiology Part A 136 (2003) 95–112.  PDF available here.

Wednesday, December 15, 2010

Weekly Strength Training Provides Long-Term Cognitive and Economic Benefits

Joyce Mar works on her strength training at the Langara Family YMCA in Vancouver on Tuesday.

Photograph by: Steve Bosch, Vancouver Sun, Vancouver Sun

Today the Archives of Internal Medicine published results of a study that found that women aged 65 to 75 years who engaged in progressive strength training once or twice weekly over 12 months had improved executive cognitive functions and lower medical care costs than control women when evaluated again one year later.

Today's publication provides a follow-up on the Brain Power study which the Archives of Internal Medicine published inpublished in its January 2010 issue.  The original study demonstrated that 12 months of once-weekly or twice-weekly progressive strength training improved executive cognitive function in women aged 65- to 75- years- old.  

 One report of the the study results released today states:

Both studies were led by Teresa Liu-Ambrose, principal investigator at the Centre for Hip Health and Mobility and Brain Research Centre at Vancouver Coastal Health and UBC, and assistant professor in the Department of Physical Therapy at UBC's Faculty of Medicine. The one year follow-up study found the cognitive benefits of strength training persisted, and with two critical findings.

"We were very surprised to discover the group that sustained cognitive benefits was the once-weekly strength training group rather than the twice-weekly training group," says Liu-Ambrose, who's also a Michael Smith Foundation for Health Research scholar. "What we realized was that this group was more successful at being able to maintain the same level of physical activity achieved in the original study."

In this study, one group did once-weekly strength training, another did twice-weekly strength training, and a third group "control" group did something the authors refer to as "balance and tone" which according to a Vancouver Sun article featured "stretching, range of motion, core strength, balance and relaxation exercises." 

According to the report, only the once-weekly group maintained the cognitive benefits at the follow-up.  Strength training may keep you smarter than doing "balance and tone" training.

 Regarding economic benefits:

The second important finding relates to the economic benefits of once-weekly strength training. Using the data from the Brain Power Study and the one-year follow-up study, health economists Jennifer Davis and Carlo Marra, research scientists with the Collaboration for Outcomes Research and Evaluation at St. Paul's Hospital and UBC Faculty of Medicine, were able to show that the economic benefits of once-weekly strength training were sustained 12 months after its formal cessation. Specifically, the researchers found the once-weekly strength group incurred fewer health care resource utilization costs and had fewer falls than the twice-weekly balance and tone group.

"This suggests that once-weekly resistance training is cost saving, and the right type of exercise for seniors to achieve maximum economic and health benefits," says Davis.

The study found that the once-weekly strength training group had the fewest fall and lowest medical care utilization costs. 

Thus,  this study shows that standard strength training helps seniors maintain balance more effectively than exercises supposedly dedicated to "core" strength, balance, and range of motion.  That's partly because maintaining balance requires muscular strength.  If your inner ear detects that you are off balance, but you lack the strength required to correct the movement, you will fall.  Moreover, a properly designed strength training routine will itself provide so-called "core" strength, balance training, and movement through full ranges of motion.  

In other words, strength training does it all in just one session per week.

Stay strong, stay smart, stay healthy.

The Blood Type Diet: A Critical Perspective

01/20/14 UPDATE:   On January 15, 2014 Wang et al published an empirical test of the central claim of the blood type diet hypothesis, i.e. that each blood type benefit more from one particular diet than others.  Confirming what I wrote in this post in 2010, Wang et al concluded: "Adherence to certain ‘Blood-Type’ diets is associated with favorable effects on some cardiometabolic risk factors, but these associations were independent of an individual's ABO genotype, so the findings do not support the ‘Blood-Type’ diet hypothesis." Read the full text in PLOS One.  Read my blog about the study here.

Thanks to Peter J. D’Adamo, N.D. , author of the book Eat Right 4 Your Type, many people believe that blood type determines your dietary requirements and that only people with O-type blood should eat a paleo/primal diet.  

In this post I will discuss all the errors in this blood type hypothesis. 
The Blood Type Diet Hypothesis

D’Adamo’s hypothesis can be distilled down to four main claims and a conclusion drawn from these claims.

Claim A: Evolutionary adaptation to diet patterns resulted in the ABO blood groups, so each of the four types is adapted to a different type of diet and set of foods.
Claim B: People of different blood types have different antibodies in their blood and each blood type has a different susceptibility to diseases.
Claim C: Foods contain lectins that mimic blood group antigens and selectively cause blood agglutination (i.e. each food affects each blood group differently), and this causes diseases.
Claim D: Exposure to foods containing lectins incompatible with your blood type will cause agglutination of your blood which will cause diseases. As D’Adamo puts it, the lectins “target  an organ or bodily system and begin to agglutinate blood cells in that area.”

Conclusion: Therefore, people require diets tailored to their blood types, eliminating foods that have harmful lectins for their blood type.

The Four Diets

Blood type O

According to D’Adamo,  O-type blood is the “Original” blood type which evolved when humans lived by hunting supplemented by gathering.  He says these people should base their diets on lean meat and fish, supplemented with a selection of fruits and vegetables he deems suitable for this blood type.  O-types should avoid or greatly minimize dairy products and minimize or avoid grains and beans, particularly wheat.  According to D’Adamo, people with O-type don’t tolerate wheat “at all” yet he also says that they can eat sprouted wheat products (?).

Blood type A

D’Adamo claims that A-type blood arose as an adaptation to agriculture; conveniently, A is for agriculture.  He claims that this type can eat grains (except wheat), beans, most seafoods, many vegetables and  fruits, but should avoid dairy, meat, wheat, kidney beans, and lima beans.  He states that only people with A-type blood can and should eat a vegetarian diet.
Blood type B

D’Adamo refers to B-type as  “The Nomad.”  He implies that this type arose as an adaptation to pastoral lifestyles based on use of dairy products and meat from domesticated animals.  He states that B-types are adapted to a “balanced omnivore” diet that meat (but no chicken), eggs, dairy, beans, fruits, vegetables.  He advises people having the B blood type to avoid chicken, corn, lentils, peanuts, sesame, buckwheat, and wheat.

Blood type AB

D’Adamo calls type AB blood “The Enigma” and states that people having this blood type are adapted to a “mixed diet in moderation.   He advises that they can safely eat lamb, mutton, rabbit, turkey, pheasant, most seafood, dairy, beans, grains,             fruits,             and vegetables, but should avoid beef, chicken, kidney beans, lima beans, seeds, corn, buckwheat.

Basic Errors

As someone basing his whole approach to diet on blood types, D’Adamo appears disturbingly ignorant of basic facts about the evolution of the ABO types.

First, he claims that the O-type is the original blood type. He published his book in 1994, but by 1990 molecular biologists had determined that A-type is the original blood type.   In “Evolution of Primate ABO Blood Type Genes and Their Homologous Genes [full text available free],” Saitou and Yamamoto state [p. 405]:

“..the common ancestral gene for the hominoid and Old World monkey ABO blood
group is A type, and three B alleles evolved independently on the human, gorilla, and baboon lineages.”

The fact that both A-type and B-type antedate O-type seems predictable from the fact that O-type blood carries antibodies to A-type and B-type blood; for this to happen, O-type blood had to have emerged in an environment in which A-type and B-type antigens (the markers on A- and B- type blood cells) already existed. 

D’Adamo suggests that the blood types arose in humans as adaptations to dietary variations, implying that they are unique to humans.  In fact, ABO blood types occur not only in humans, but also in other primates.  Again, according to Table 5 in Saitou and Yamamoto, which presents data dating to 1964, more than 30 years before D’Adamo published his books:
·      The A phenotype occurs in chimps, orangutans, gibbons, baboons, Java macaques, sulawesi crested macaques, and squirrel monkeys (7 speicies).
·      The B phenotype occurs in gorillas, orangutans, gibbons, baboons, Rehsus macaques, pigtailed macaques, Java macaques, sulawesi crested macaques, and cebus monkeys (9 species).
·      The AB phenotype occurs in oragutans, gibbons, baboons, and Java macaques (4 species).
·      The O phenotype occurs in chimps, Java macaques, squirrel monkeys, and cebus monkeys (4 species).

Since none of these primates have ever practiced agriculture or domesticated dairy animals, it is clear that the A allele did not evolve as an adaptation to agriculture nor did the B allele emerge as an adaptation to consumption of dairy products. 

As noted above, the B-type has been found in the largest selection of species (9), followed by the A-type (7), and both O- and AB- type occur in the smallest selections (4 species each).  According to Saitou and Yamamoto, among this list of primates checked for ABO blood type, A phenotype occurred in 191 individuals, B in 75 individuals, AB in 44 individuals, and O in 20 individuals. 

According to Saitou and Yamamoto “It seems that the time of gene dupulication producing ABO and GAL genes may be around the emergence of vertebrates (ca. 500 MYA).”  [p.408]  In other words, these blood types have a much longer history than human dietary variations. 

Human Data

Its possible that D’Adamo did not mean to imply that the blood types arose only in humans.  Perhaps he meant that human adoption of hunting lifestyle selected for O-type, agriculture for A-type, and pastoralism for B-type.  In this case, we should find a predominance of O-type among all ethnic groups with a long history of living by hunting, especially those eating little plant food; a predominance of A-type among  ethnic groups having the longest histories of practicing agriculture; and a predominance of B-type among ethnic groups with long histories of pastoralism.

Unfortunately, the available data does not support this either.  So far as we know, Eskimos have never practiced agriculture or animal husbandry, and have long lived primarily by hunting, a diet enforced by their environment.  D’Adamo’s hypothesis would predict that Eskimos would have predominantly O-type blood.  According to, this is true of Greenland Eskimos (54% O, 36% A), but not of Alaskan Eskimos (38% O, 44% A), who have more A-type than O-type individuals, contradicting D'Adamo's hypothesis.

According to Wikipedia and, people of the Blackfoot or Niitsítapi tribe traditionally lived primarily on buffalo meat; classic hunters.  From Wikipedia:

“While the Niitsitapi were in the Great Plains, they came to depend on the buffalo (American bison) as their main source of food. The bison are the largest mammals in North America and stand about 6 ½ feet tall and weigh up to 2,200 pounds.[6] Before the introduction of horses, the Niitsitapi had to devise ways of sneaking up close to the buffalo without the animals' noticing so they could get in range for a good shot. The first and most common way for them to hunt the buffalo was using the buffalo jump. The hunters would round up the buffalo into V-shaped pens and drive them over a cliff (they hunted prong-horned antelopes in the same way). After the buffalo went over the cliff, the Indians would go to the bottom and take as much meat as they needed and could carry back to camp. They also used camouflage for hunting.[6] The hunters would take buffalo skins from previous hunting trips and drape them over their bodies to blend in and mask their scent. By subtle moves, the hunters could get close to the herd. When close enough, the hunters would shoot the bison with arrows, or use lances and spears to bring them down.

They used virtually all parts of the body and skin. They prepared the meat for food: by boiling, roasting and drying for jerky. This prepared it to last a long time without spoiling, and they depended on bison meat to get through the winters.[7] The winters were long, harsh, and cold due to the lack of trees in the Plains, so the people stockpiled the meat when they had the chance.[8] The hunters often ate the bison heart minutes after the kill, as part of their hunting ritual. The skins were prepared and used to cover the tepee. The tepee was made of log poles with the skin draped over it. It remained warm in the winter and cool in the summer, and a great shield against the wind.[9] With further preparation of tanning and softening, the women made special clothing from the skins: robes and moccasins. They rendered bison fat to make soap. Both men and women made utensils, sewing needles and tools from the bones, using tendon for fastening and binding. The stomach and bladder were cleaned and prepared for use as containers for storing liquids. Dried bison dung was fuel for fires. the fires. The Niitsitapi used almost every part of the buffalo and considered it a sacred animal, integral to their lives.[10]”

From this D’Adamo would predict that they had primarily O-type blood.  Wrong again. states that 82% of Blackfoot people have A-type blood, and only 17% have O-type. 

Looking from the other side, D’Adamo’s hypothesis would predict that Cantonese Chinese would have a higher incidence of A-type and lower incidence of O-type because they have lived for millennia on a rice-based agricultural diet. states that Cantonese Chinese have 46% O- and 23% A- types, the reverse of the D’Adamo prediction. 

Meanwhile, the northern Chinese (Peking) have 29% O, 27% A, and 32% B, a distribution which according to D’Adamo’s hypothesis would predict that the population has a long history of living on dairy products.  Unfortunately for D’Adamo, the pastoral lifestyle is not common in China at all, only practiced by Chinese in the western, mountainous provinces.

Just as one black swan is sufficient to disprove the claim that all swans are white, these few counter examples are sufficient to disprove the claims that hunting-based subsistence favors the O-type blood, while an agricultural subsistence favors the A type blood.  D’Adamo is just wrong when he asserts that dietary differences drive differences in distribution of blood types among humans. 

No Anatomical Evidence

All humans, regardless of blood type, cultural background, or  diet histories have the same basic gut design, dentition (number and type of teeth, type of enamel), type of saliva and digestive enzymes.  This is why we call them humans.  

For example, scientists have found no nutritionally relevant anatomical, physiological, or biochemical differences between Chinese and Eskimos. 

Nor are there any such differences between people with A-type and O-type blood.  

Medical Evidence?

D’Adamo claims that O-type people get ulcers more frequently than people with A-type because O-type individuals, according to him, produce more stomach acid than people with A-type blood.  He says that O-types produce this greater amount of acid as an adaptation to a high meat diet; A-types have less acid because they are adapted to a low protein, low meat diet. 

Apparently he missed the memo when research discovered that gastric ulcers arise from infection with H. pylori bacteria, not excessive stomach acid production.  While it is true that group O individuals have approximately 35% greater risk of gastrointestinal ulcer when compared to group A individuals, this is not because O-types produce more acid that A-types.   The ulcer-causing bacterium, H. pylori, can more easily attach to the G.I. lining of Group O, because it has a protein structure that mimics the Group O host (which confuses the host’s immune system).  In contrast, the immune system of A-type individuals more easily recognizes the bacterium as a foreign invader, making them more resistant to this infection.

D’Adamo correctly states that group A individuals have a higher risk of cancer than group O individuals.  Relative to Group O individuals, Group A individuals have higher risks of cancers of stomach , colon, ovary, uterus, cervix, and salivary glands (relative risks 1.2, 1.11, 1.28, 1.15, 1.33, and 1.64).  D’Adamo implies that this difference arises due to influence of dietary lectins. Presumably, the more vegetarian diet  he prescribes for A-types will protect them from cancer by reducing their exposure to harmful lectins.

First of all, if dietary lectins are the cause of cancers in anyone, it is very hard to understand how a vegetarian diet based on grains and beans will help prevent cancer.  Lectins are carbohydrate-binding proteins found in the highest concentrations in carbohydrate-rich foods like gains, legumes, and potatoes, not meat.  From Wikipedia entry on lectins:

“The toxicity of lectins has been identified by consumption of food with high content of lectins, which can lead to diarrhoea, nausea, bloating, vomiting, even death (as from ricin). Many legume seeds have been proven to contain high lectin activity, termed as hemagglutinating activity. Soybean is the most important grain legume crop, the seeds of which contain high activity of soybean lectins (soybean agglutinin or SBA). SBA is able to disrupt small intestinal metabolism and damage small intestinal villi via the ability of lectins to bind with brush border surfaces in the distal part of small intestine. Heat processing can reduce the toxicity of lectins, but low temperature or insufficient cooking may not completely eliminate their toxicity, as some plant lectins are resistant to heat.”

Therefore, the diet he apparently prescibes to A-types to reduce their risk of cancer actually provides MORE potentially hazardous dietary lectins than the diet he prescribes to O-types.

Secondly, D’Adamo doesn’t appear to know that the reason for increased risk of cancers in individuals with A-type blood is similar to the reason for the increased risk of ulcers in individuals with O-type blood.  Tumors often express an A-like antigen that the immune system of an A group individual will accept as “self” while the immune system of an O or B group individual will attack any cell with an A antigen. 

Note also that group O- and B- individuals still get these tumors. For example, the relative risk of stomach cancer is only 20% greater among A-type individuals compared to O-type.  This means that if 5 of 100 individuals having blood type O get stomach cancer, 6 of 100 individuals having blood type A get the same cancer; if 50 type Os get the cancer, 60 type As will get it.  In absolute numbers, the difference between these groups is not significant. 

Do Lectins Cause Selective Agglutination?

A lynch pin of D’Adamo’s hypothesis is the claim that lectins selectively cause agglutination in different blood types.  For example, according to D’Adamo, people with B-type blood should avoid chicken because it contains lectins that will agglutinate blood in these individuals, but not in people with other blood types.

We don’t have any evidence for this.  In fact, published data indicates that any individual lectin will affect all blood types in essentially the same way. 

Wikipedia discusses this topic:

“D'Adamo claims there are many ABO specific lectins in foods.[14] This claim is unsubstantiated by established biochemical research, which has not found differences in how the lectins react with a given human ABO type. In fact, research shows that lectins which are specific for a particular ABO type are not found in foods (except for one or two rare exceptions, e.g. lima bean), and that lectins with ABO specificity are more frequently found in non-food plants or animals.[15][16]

The Nachbar Study[17] has been cited in support of D'Adamo's theories, because it reports that the edible parts of 29 of 88 foods tested, including common salad ingredients, fresh fruits, roasted nuts, and processed cereals were found to possess significant lectin-like activity (as assessed by hemagglutination and bacterial agglutination assays). However, almost all of the 29 foods agglutinated all ABO blood types, and were not ABO blood type specific. Since D'Adamo's theory has to do with lectins in food that are "specific for a certain ABO blood type", this study does not support his claim that there are many ABO specific lectins in foods.”

Reference 15 in this excerpt refers to The Handbook of Plant Lectins

So Why Do People Feel Better?
D’Adamo advises the avoidance of wheat to O, A, and B blood types. Collectively, these comprise 96% of all people in the U.S..  Therefore, most people who read the book will get advice to avoid wheat, and they may try it.  This alone will improve health for some people who are wheat sensitive. 

Besides this, most people adopting the blood type diet will simply make general improvements to their diets, like reducing sugar intake, eating less processed and more unprocessed foods. D’Adamo suggests these steps to all blood types.  The general steps will help most people feel significantly better and perhaps lose some body fat. 

Bottom Line

The blood type diet does not have a solid leg on which to stand.  The hypothesis is riddled with errors. 

Addendum 10/28/11

Michael Klaper, M.D.: Challenges to the Blood Type Diet

Tuesday, September 14, 2010

4000 IU Vitamin D Daily Cuts Preterm Birth Risk in Half

A new study by researchers from Medical University of South Carolina has found that women taking 4000 IU of vitamin D daily during pregnancy cut their chances of a preterm birth in half compared to women taking only 200-400 IU.  The women taking 4000 IU of vitamin D also has a reduced risk of infections.  There were no adverse effects found for this level of supplementation.  

If you think you live in a sunny environment and don't need vitamin D, consider this:
"All the women taking part in the study were living in Charleston — in sunny South Carolina. Overall, 85 per cent were either insufficient, or "frankly deficient" in vitamin D when the study began."

This adds to the list of studies indicating that the vast majority of urbanites are deficient even if they live in sunny places.  

Canada's Health Care System in Financial Crisis

Just as the U.S. has started moving toward a Canada-esque health care system, the Canadian
Organisation for Economic Cooperation and Development has announced that Canada's health-care system is in a financial crisis, and needs significant -- if controversial -- reform to survive.

Read more:
Some bits from the report:
"Canada should end its status as the only OECD country -- other than the United Kingdom -- that mandates solely government funding of medical care, and allow co-payments and deductibles. Having to pay a modest fee to visit a doctor would limit government spending, likely reduce demand on the system and possibly encourage healthier lifestyles."

"The report notes that, with governments funding the entire cost of medical service and user charges outlawed, cost pressures and rising demand have forced healthcare rationing: long queues for some services and a shortage of physicians. "

Contracts for health services, especially hospital services, should be opened up to both private and public facilities. As with any government contracting process, this could "stimulate public-sector accountability."

People should be allowed to buy private health insurance and opt out of the public system for some basic medical services "at the margins" of the system, spurring on private health providers and generating competition to the public sector. To make the idea work well, doctors should be able to serve both publicly and privately funded patients."

Read more:

Friday, August 20, 2010

Fructose Feeds Cancer Follow-up: Is all fructose metabolized in the liver?

In response to my posting entitled Fructose Feeds Cancer, which referred to the Reuters story entitled Cancer Cells Slurp Up Fructose, some commenters on my blog and other bloggers have stated that fructose gets metabolized by the liver so doesn't make it into the blood stream and couldn't promote cancer anywhere but in the liver. 

I dissented and today took a moment to search for studies measuring fructose concentrations in the blood.  My first find was Increased Fructose Concentrations in Blood and Urine in Patients With Diabetes published in Diabetes Care.  From the abstract:

"Serum fructose concentrations in patients with diabetes (12.0 ± 3.8 μmol/l) were significantly higher than those in healthy subjects (8.1 ± 1.0 μmol/l, P < 0.001) and nondiabetic patients (7.7 ± 1.6 μmol/l, P < 0.001), and daily urinary fructose excretion was significantly greater in patients with diabetes (127.8 ± 106.7 μmol/day) than in nondiabetic patients (37.7 ± 23.0 μmol/day, P < 0.001)."

So there you have it.  Non-diabetics, healthy subjects, and diabetics all have fructose in serum, with the diabetics carrying an average of about 50% more fructose in serum than healthy subjects. 

If you read the full text, you will learn that inadequate technology once made detection of fructose in serum difficult, and the authors of this study overcame that limitation.  You will also see this discussion of several mechanisms which might explain increased fructose in serum of diabetics:

"First, impaired fructose metabolism in the liver might play an important role, given that several studies have shown that the liver metabolizes at least half of all fructose (11,13). Second, the transport system for fructose might be disrupted. Fructose is transported into the liver, at least in part, by the same system as glucose and galactose (14,15). In adipocytes, fructose can enter by at least two different carriers. Hajduch et al. (16) reported that GLUT5 was responsible for mediating ∼80% of the total cellular fructose uptake, whereas the remaining 20% was cytochalasin B-sensitive, which most likely reflects transport via GLUT1 and/or GLUT4. Third, the polyol pathway might play a role in the increment of serum and urinary fructose concentrations. This pathway reportedly contributes to increased fructose concentrations in many tissues of patients with diabetes (17) and diabetic animals (1820)."

Notice that the authors say "the liver metabolizes at least half of all fructose,"  not "the liver metabolizes all of ingested fructose."  Also, they cite four studies that found increased fructose concentrations in "many tissues" of diabetic humans and animals.  To get to those tissues it had to go through the blood from the gut.  These findings clearly indicate that the development of diabetes involves a rise in serum and tissue levels of fructose, providing fuel for cancer proliferation in affected tissues.  And we don't have to eat an diet of 100% fructose to get this result.  

Some might scoff at the micromolar concentrations but the authors also point out that fructose is so much more reactive than glucose that it has comparable pathological effects even at these very low concentrations:

"Although glucose circulates in millimole concentrations, only ∼1/1,000 molecules circulates as a free aldehyde and can therefore participate in glycation reactions. Fructose, although circulating in micromole concentrations, is much more reactive in this regard and, therefore, may be comparable to glucose in terms of mediating pathology through nonenzymatic reactions and downstream processes."

Thursday, May 27, 2010

Exercise and Fitness Buffer the Life-Shortening Effects of Psychological Stress

A new article published in the on-line Public Library of Science journal reports on a study which compared the effects of chronic psychological stress on either sedentary or physically active people.

The study involved looking at telomere length in 63 healthy post-menopausal women. The researchers measured telomere length in the women, then had the women complete the Perceived Stress Scale. After this, for three days the women reported their daily investment of time (in minutes) in vigorous physical activity. The researchers then calculated the likelihood of having long or short telomeres relative to age, body mass index, education, perceived stress, and activity level.

Among the sedentary women, each unit of increase in perceived stress (on the Perceived Stress Scale) was associated with a 15-fold greater odds of having short telomeres, a marker of biological aging. However, among those who got an average of at least 14 minutes daily of vigorous exercise, the researchers found no increase in odds of short telomeres regardless of perceived stress.

In other words, it appears that people who engage in sufficient, but not excessive, physical activity have greater resistance to the aging effects of psychological stress.

The authors propose several explanations for the beneficial effects of activity:

1. Moderate physical activity appears to increase endogenous antioxidant production, which may buffer the pro-oxidative effects of stress.
2. Physical fitness and activity appear to blunt neuroendocrine responses to stress, particularly reducing sympathetic nervous system responses and cortisol production.
3. Physical activity appears to reduce cognitive rumination (i.e. it quiets the mind), which results in less sympathetic nervous system activity and lower cortisol production under stress.

In short, this study suggests that by engaging in regular physical activity we protect ourselves from both the immediate and the aging effects of stress. We would expect this from a species that evolved by route of a lifestyle that required physical activity in the pursuit of food. Proper exercise is essential to not only physical but also mental health.

Wednesday, April 21, 2010

Practically Paleo Perspective: Rice

A commenter asked me for my opinion on rice, so here you have it.

[Updated 4/20/12:  The original version of this post illustrates some of the poor reasoning I fell into as a result of reading books and blogs by people advocating paleo diet, while ignoring the bulk of research on diet and health.  My critiques and corrections of the original appear in brackets.]

Botany and Antinutrients

Rice is the seed of a monocotyledonous plant known to botanists as Oryza sativa. 

Like other seeds, whole (brown) rice contains chemical defenses against predation, primarily present in the hull and bran of the seed.  They include phytin (phytate), trypsin inhibitor, oryzacystatin and haemagglutinin-lectin.

Phytate binds minerals including calcium, zinc and iron; it also binds with protein.  Heat (cooking) does not denature phytate.  Studies have found that subjects fed brown rice diets have poorer mineral balance when compared to subjects fed milled rice diets.  On the other hand, phytate protects against dental caries, so white rice promotes dental decay more than brown rice.

[4/20/12:   Phytate fears are not founded on good science.  Science does not support claims that dietary phytate causes harm to humans.  Humans adapt to phytate ingestion, dietary vitamin C cancels the negative effect of phytate on mineral absorption, phytate adversely affects mineral balance only if the diet is deficient in minerals, and research has shown that dietary phytate has a strong health benefits for prevention and treatment of cardiovascular disease and cancer; it even inhibits the growth of malignant tumors.]

Trypsin inhibitor occurs in rice bran.  Steaming rice bran at 100 degrees C (212 F) inactivates trypsin inhibitor.  [4/20/12:  This means that boiled brown rice has no active trypsin inhibitor.] Polishing rice eliminates trypsin inhibitor.

Haemagglutinins  or lectins consist of globulins that agglutinate mammalian red blood cells and precipitate glycoconjugates or polysaccharides. Lectins bind to specific carbohydrate receptor sites on the intestinal mucosal cells and thus interfere with the absorption of nutrients across the intestinal wall.  Rice lectin agglutinates human A, B and O group erythrocytesAccording to the FAO, rice lectin sharply loses activity when heated to 100 degrees C. [4/20/12: Hence, since we boil rice at 100 degrees C before eating it, we don't have to worry about this lectin.]

Oryzacystatin is an inhibitor of protein-digesting enzymes.  Oryzacystatin remains 100% active after at least 30 minutes of boiling.

Rice also contains an allergenic protein that occurs primarily in the milled rice, not the bran, and remains stable (60%) even after boiling for 60 minutes at 100 C (212 F).

[4/20/12: Rice allergies occur in only 10% of atopic patients in Japan and less in Europeans and Americans.  Compare this to beef allergy:

"The prevalence of beef allergy is between 3% and 6.5% among children with atopic dermatitis and can be up to 20% in cow's milk allergic children. Several studies reported an incidence of 1-2% of food-induced anaphylactic reactions caused by ingestion of beef. In another study an even higher figure of 9% of anaphylactic events from foods were induced by beef."
These data appear to indicate a much greater incidence of anaphylactic events triggered by beef than by rice.]
Nutritional value

Rice has a very high carbohydrate content and low levels of micronutrients compared to vegetables or fruits.  The following table compares the levels of selected vitamins and minerals in 50-kcal portions of brown rice and a selection of vegetables and fruits.  Red numbers indicate items with the highest levels among the foods compared. Click on image to see larger version.

Notice that brown rice does not have the highest level of any of the nutrients listed.  White potatoes have twice as much riboflavin (B2), 2.5 times as much folate, vitamin C not present in rice, 10 times more potassium, more than 3 times as much iron, and 25% more calcium than brown rice.    Sweet potatoes supply carotenes (provitamin A) and vitamin C not present in brown rice, three times as much B2, 5.5 times as much folate, 9 times as much potassium, slightly more iron, and more than 3 times as much calcium.  Winter squash also makes brown rice pale in comparison.

Strawberries have 10 times as much B2, 12.5 times as much potassium, nearly 3 times as much iron, and more than 5 times as much calcium.

No matter which vegetable or fruit you compare to brown rice, you find the vegetable or fruit makes brown rice pale in comparison.

Then if you compare brown to white rice:

Brown Rice vs. White Rice

Brown Rice (1 cup)
White Rice (1 cup)
Energy (kcal)
Protein (g)
Carbohydrate (g)
Fat (g)
Fiber (g)
Thiamin (mg)
0.3 (synthetic)
Riboflavin (mg)
0.03 (synthetic)
Niacin (mg)
2.8 (synthetic)
Pyridoxine (mg)
Folacin (mcg)
109.8 (synthetic)
Calcium (mg)
2.7 (fortified)

Laying aside the synthetic fortification, brown rice supplies nearly 3 times as much pyridoxine, 10 times as much calcium, almost 6 times as much magnesium, more than 3 times as much phosphorus, more than 3 times as much potassium, and almost twice as much zinc.  Therefore, white rice doesn't hold a candle to brown rice, and brown rice doesn't hold a candle to white potatoes.

[4/20/12:  Turn this around, and judge by energy, protein, and carbohydrate delivery per unit volume, and you find that brown rice surpasses non-starchy vegetables and fruits.  We need some foods for energy and macronutrients, and some foods for micronutrients.  Brown rice is a nutrient-dense starch and energy source compared to white rice.]

White or brown, rice is basically filler with little nutritional value compared to vegetables and fruits.  If you eat rice, you crowd out more nutrient-dense sources of carbohydrate. 

[4/20/12:  Wow, what a ridiculous argument!  Both brown and white rice are much more nutrient-dense than fats like butter, lard, and olive oil, so I would have been more correct to state that fats are fillers compared to brown rice.  When I compared the micronutrient content of two equicaloric diets, one high in meat and supplying most of its energy from fat, and the other low in meat and supplying most of its energy from starches like brown rice, the starch-based diet won hands down.]


Environmentalist vegetarians like to blame livestock for global warming, but according to Wikipedia:

In many countries where rice is the main cereal crop, rice cultivation is responsible for most of the methane emissions....Methane is twenty times more effective as a greenhouse gas than carbon dioxide.
[4/20/12:  This is an example of the half-truths used to support paleo perspectives.  How about taking a look at relative contributions of rice compared to animal products?  A study published in the American Journal of Clinical Nutrition calculated the amounts of greenhouse gases (carbon dioxide, nitrous oxide, and methane) emitted in the production of 22 different commonly consumed foods, in kg of CO2 equivalents per kg of final product:   Rice, 1.3;  eggs, 2.5; rapeseed oil, 3.0; chicken, 4.3; cod, 8.5; pork, 9.3; cheese, 11; beef, 30.  So the favored foods of low carb and paleo diets produce 2 to 23 times as much greenhouse gas emissions as rice.]

Further, rice fields are the principal breeding grounds for mosquitos that carry malaria.

So there you have my perspective on rice.   I do not recommend regular consumption of either brown or white rice. [Line through added on 4/20/12.]

[4/20/12:  I now highly recommend eating rice and other grains as staple foods, and I no longer recommend eating eggs, poultry, fish, pork, or beef or beef products.  Grains are far superior to meats and fats as human energy sources and for health support, and have much less deleterious effect on the environment.  Science has shown us that meat- and fat-based paleo dieting is not beneficial to human health, animal welfare, or for ecosystem preservation.]

Sunday, April 4, 2010

Paleo Strength Works For Women Too; and Paleo Kits

Kristen Onesi Liberati pulls some heavy weight, showing women their potential:

Kristen's husband Steve Liberati heads Steve's Club, a Crossfit Affiliate in Camden, New Jersey with a unique mission:

Steve's Club is a 501(c)(3) non-profit organization offering young athletes (and non-athletes) of Camden, NJ world-class coaching, community and training techniques used by elite and professional athletes worldwide to help strengthen the foundation of our future.

Specifically, Steve helps at-risk kids grow into productive, positive people through Crossfit training.  I resonate with Steve's message:

 "The greatest discovery any alien outsider could make about Camden is its overriding response to failure: If it didn’t work last year, do it AGAIN this year (and if possible do it MORE). Every year they pass more laws, hire more police, build more prisons, and sentence more offenders for longer periods-all without moving one inch closer to “ending” crime. If it didn’t work last year or the year before that or the year before that or the year before that, but you can be sure we’ll try it again this year, knowing beyond a shadow of a doubt that it won’t work this year either. Every year they spend more money on schools, hoping to “fix” whatever’s wrong with them, and every year the schools remain stubbornly unfixed. Spending money didn’t work last year or the year before that or the year before that, but you can be sure we’ll try it again this year, knowing beyond shadow of a doubt that it won’t work this year either. Every year they try to make the criminals go away, and every year they remain with us. We couldn’t shoehorn these criminals back into the “the mainstream” last year or the year before that or the year before that or the year before that, but you can be sure we’ll try it again this year, knowing beyond a shadow of a doubt that it won’t work this year either. Maybe its time to TRY something DIFFERENT. Afterall, IF Camden is saved, it will not be saved by old minds with new programs but by new minds with no programs at all."
How fitting that Steve has the surname Liberati -- the liberator!

I would substitute for Camden the name of any "government" and it would remain just as true.  Try this:

After all, IF the U.S. is saved, it will not be saved by old minds with new programs but BY NEW MINDS WITH NO PROGRAMS AT ALL.

New minds realize that programs don't work because they attempt to impose order from top down.  True social order comes from the spontaneous interactions of healthy human hearts and minds, which generate community from bottom up.  The way Steve and the rest of us do it.

The very highest [ruler] is barely known by men.
Then comes that which they know and love,
Then that which is feared.
Then that which is despised.

He who does not trust enough will not be trusted.

When actions are performed without unnecessary speech,
People say, "We did it [ourselves]!"

Tao Te Ching, Chapter 17.

Politicians act as if they have expertise in all aspects of human behavior, economics, health care, nutrition, science, automotive manufacturing, insurance....on and on; they believe and want us to believe that they have qualifications to tell everyone how to do everything from birth to death.  But as Steve points out, their "programs" rarely if ever address root causes, and their abundant failures demonstrate that they don't have a clue how things or people work.  In fact if you trace the loop you will find that their "programs" create the problems, not solve them.

The more laws and restrictions there are,
The poorer people become.
The sharper men's weapons,
The more trouble in the land.
The more ingenious and clever men are,
The more strange things happen.
The more rules and regulations,
The more thieves and robbers.

Therefore the sage says:
I take no action and people are reformed.
I enjoy peace and people become honest.
I do nothing and people become rich.
I have no desires and people return to the good and simple life.

Tao Te Ching, Chapter 57

Obviously few if any politicians are sages, most are goons.  I would call them clever--like a cleaver, good at splitting things apart, as in divide and conquer--but not intelligent or even less, wise.

Take the red pill, and you see their game:  They keep stealing more and more of our time and productivity from us (via taxes),  leaving us less and less capable of caring for our families, friends, and communities on our own.  Even under these circumstances we do our best to help one another, but when half your income goes to the goons with the biggest guns ("government"), you have to keep almost every thing you make for your self and don't have much extra available to help your extended family, friends, or community.  Then the goons say "Look at how evil you masses are, you guys don't care for your own, you need our Programs."  So then they raise taxes and tyranny up another notch with the claim that this will "help" the people.  Taoists saw through the game thousands of years ago:

Why are the people starving?
Because the rulers eat up the money in taxes.
Therefore the people are starving.

Why are the people rebellious?
Because the rulers interfere to much.
Therefore they are rebellious.

Why do the people think so little of death?
Because the rulers demand to much of life.
Therefore the people take death lightly.

Having little to live on, one knows better than to value life too much.

Tao Te Ching, Chapter 75.

Politicians and other misanthropists would have us believe that without their top-down interference in our lives no one would take care of anyone else, that people like Steve don't exist.  They want you to believe that if they didn't "control" your life with their "programs" we would live in chaos, going at each other's throats with machetes.  I can't think of anything more bullshit than this, and I believe that Steve and you also, my dear reader, prove it.  Just look at your life.  Have you not done your best to do more good than harm?  Do you not help the helpless when you can?  Do you not care for children and do your best to support the youth and care for the elders?

Why?  Humans evolved as cooperative creatures engaged in  cooperative hunting and gathering, sharing food, mutual aid in times of need, and mutual protection from predators. Natural selection favored cooperation and devotion to family and friends, and especially the youth and elders who had experience.  Tribes full of people who cooperated and loved children and taught them well certainly had more descendants than tribes full of miscreants who couldn't care less about their children.  Cooperative people not only survived, they thrived, and jerks either had no mates, rightfully got the death penalty directly, or got expelled from the tribe to deal with the wild cats on their own (good riddance and good luck!).

Don't let the misanthropes, the control freaks, the goons and thugs, define you in their own image, as a beast. Stand up and claim your humanity.   You would put their tax and tyranny schemes to shame by naturally living out paleolithic "ethics," if you just let your human nature free and put your intelligence and love into helping your family, friends, and community.

Steve supports the club in part by producing Paleokits:

I bet you'll support them when you see their purpose, because I feel pretty confident you wouldn't read this blog if you didn't have a compassion ten times larger than a politician's cleverness.